Lattice Graph × LiquidStack

Lattice Graph is a computational materials-discovery platform built to compress the timeline between a chemical need and a licensable, validated material. At its core sits a knowledge graph spanning millions of compositions, connected across thermodynamic phases, synthesis routes, patent claims, and experimental outcomes. Every candidate that surfaces from that graph must earn consensus stability: independent machine-learning interatomic potentials — MACE, CHGNet, MatterSim, and ORB — must agree on phonon and thermodynamic stability before a composition advances, and density functional theory validation runs on the candidates that clear that bar. This multi-model consensus approach filters out the vast majority of computational false positives before any experimental resource is spent. Beyond stability screening, the platform runs targeted simulations calibrated to the property specification a program actually cares about — dielectric breakdown voltage, vapor pressure curve, surface tension, thermal conductivity, or corrosion inhibition, depending on the application. A freedom-to-operate and patent-whitespace engine covers more than 300,000 materials patents at composition and claim level, so every asset that reaches a licensing conversation carries a clear IP picture. The platform also maintains a large atlas of labeled negative results — failed experiments — which shortens the search space by ruling out dead ends that have already been explored elsewhere.

LiquidStack built its two-phase immersion-cooling systems around a class of fluorinated fluids — 3M Novec products chief among them — that combined the dielectric breakdown retention, low global-warming-potential alternatives, and closed-loop reusability that the thermal architecture demanded. With Novec exiting the market and PFAS-free regulation tightening globally, LiquidStack is not facing a supplier disruption; it is facing a materials-supply crisis at the foundation of its product line. Finding a drop-in successor that meets the same dielectric and reuse specification, without fluorinated chemistry, is an existential commercial requirement, not a roadmap nice-to-have. Lattice Graph's primary matched portfolio — PFAS-free dielectric and process fluids — was constructed precisely to address this gap. The platform screened across a very large composition space to identify fluid candidates with verified dielectric retention, appropriate vapor-pressure curves for two-phase operation, corrosion-inhibitor compatibility, and demonstrated reuse endurance under closed-loop cycling. The lead immersion-cooling asset carries a 500-hour reuse specification and has been validated across those criteria without any organofluorine content. For LiquidStack specifically, the cleanest commercial structure is a field-of-use license keyed to qualified cooling capacity — allowing LiquidStack to continue selling its tank and distribution hardware against a licensed fluid specification rather than acquiring a chemistry business it does not need to own. That structure is already contemplated in how the portfolio's licensing terms are framed, and the freedom-to-operate picture on the primary immersion-cooling asset has been characterized at claim level across the relevant patent landscape.

LiquidStack built its two-phase immersion-cooling systems around a class of fluorinated fluids — 3M Novec products chief among them — that combined the dielectric breakdown retention, low global-warming-potential alternatives, and closed-loop reusability that the thermal architecture demanded. With Novec exiting the market and PFAS-free regulation tightening globally, LiquidStack is not facing a supplier disruption; it is facing a materials-supply crisis at the foundation of its product line. Finding a drop-in successor that meets the same dielectric and reuse specification, without fluorinated chemistry, is an existential commercial requirement, not a roadmap nice-to-have. Lattice Graph's primary matched portfolio — PFAS-free dielectric and process fluids — was constructed precisely to address this gap. The platform screened across a very large composition space to identify fluid candidates with verified dielectric retention, appropriate vapor-pressure curves for two-phase operation, corrosion-inhibitor compatibility, and demonstrated reuse endurance under closed-loop cycling. The lead immersion-cooling asset carries a 500-hour reuse specification and has been validated across those criteria without any organofluorine content. For LiquidStack specifically, the cleanest commercial structure is a field-of-use license keyed to qualified cooling capacity — allowing LiquidStack to continue selling its tank and distribution hardware against a licensed fluid specification rather than acquiring a chemistry business it does not need to own. That structure is already contemplated in how the portfolio's licensing terms are framed, and the freedom-to-operate picture on the primary immersion-cooling asset has been characterized at claim level across the relevant patent landscape.

The PFAS-free dielectric and process fluids portfolio is where the LiquidStack engagement centers. It contains the core immersion-cooling system asset — a closed-loop coolant architecture with verified dielectric-breakdown retention and a corrosion-inhibitor package — along with a broad family of twenty drop-in fluid packages that span immersion cooling, vapor cleaning, azeotropes, and electronics-cleaning use cases. Each package in that family is qualified under a common purification platform, meaning a fluid selected for LiquidStack's tank geometry would arrive with a defined electronics-grade release specification rather than requiring LiquidStack to build a qualification process from scratch. The purification and process-analytic-technology-gated release platform itself is also available, which matters if LiquidStack or a contract-manufacturing partner wants to produce the fluid rather than source it. The High-power thermal-interface materials portfolio is a secondary fit. LiquidStack's cooled-package business — the hardware that moves heat from the chip package into the fluid — benefits from thermal-interface materials with high conductivity and mechanical compatibility with the immersion environment. As AI accelerator power densities continue rising, the junction between the package lid and the cooling medium becomes a second point of thermal resistance that the immersion fluid alone cannot eliminate. The thermal-interface portfolio rounds out a complete solution that LiquidStack could present to hyperscaler and colocation customers as an integrated thermal stack, not just a tank-and-fluid replacement.

The Lattice Graph platform application gives LiquidStack's materials and engineering teams a direct interface into the knowledge graph and the simulation results behind each asset. Teams can search by target property — dielectric breakdown voltage, vapor pressure at a given temperature, surface tension, closed-loop reuse cycles — and filter across the candidate set by stability validation status, freedom-to-operate characterization, and portfolio. Each asset page surfaces the full multi-model consensus record: which potentials validated it, what the phonon stability result shows, and what DFT confirms, so an internal materials scientist can audit the computational pedigree without going back to the Lattice Graph team for every question. The freedom-to-operate screening interface accepts a composition or a composition range and returns a structured claim-level report against the 300,000-plus patent corpus, organized by assignee, claim scope, and whitespace confidence. For a company in LiquidStack's position — moving fast under commercial pressure to qualify a Novec replacement before its installed base migrates to a competitor — the ability to run that screening in the platform rather than commissioning a months-long outside counsel search is a meaningful acceleration. The application also supports collaboration workflows, so LiquidStack's legal, engineering, and procurement teams can annotate, share, and track the same asset records without data leaving a secured environment.

An engagement typically opens with a scoped technical review — Lattice Graph shares the full computational dossier for the primary immersion-cooling asset and the fluid-package family with LiquidStack's materials and thermal-engineering teams, and both sides align on which property specifications the candidate must hit given LiquidStack's tank geometry and operating envelope. That review is usually completed within two to three weeks and produces a written property-match summary that LiquidStack can use internally to justify moving to a licensing conversation. From there, the standard path is a field-of-use license with economics tied to qualified cooling capacity deployed — a structure that does not require LiquidStack to acquire IP outside its core business and that scales with its commercial success rather than requiring a large upfront payment. Lattice Graph can also layer in a freedom-to-operate screening engagement against LiquidStack's specific fluid specification and the competitive landscape, delivered as a structured report with claim-level citations. Pricing for the data and application products is available on a subscription basis that covers the knowledge-graph query access and the patent-screening API, independent of the asset license.